Selected Lab Publications

Medline publication

Saha, A. et al., Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. J Virol 83 (9), 4652 (2009).

Kaul, R. et al., EBNA3C can modulate the activities of the transcription factor Necdin in association with metastasis suppressor protein Nm23-H1. J Virol 83 (10), 4871 (2009).

Tsai, D. E. et al., EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial. Am J Transplant 8 (5), 1016 (2008).

Si, H. et al., Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation. J Virol 82 (13), 6734 (2008).

Murakami, M., Meneses, P. I., Lan, K., and Robertson, E. S., The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration. Cancer Biol Ther 7 (5), 677 (2008).

Murakami, M. et al., Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1. Int J Cancer 123 (3), 500 (2008).

Murakami, M., Kaul, R., and Robertson, E. S., MTA1 expression is linked to ovarian cancer. Cancer Biol Ther 7 (9), 1468 (2008).

Liu, Y. et al., Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology 380 (2), 264 (2008).

Lan, K. et al., Detection of Epstein-Barr virus in T-cell prolymphocytic leukemia cells in vitro. J Clin Virol 43 (3), 260 (2008).

Bajaj, B. G. et al., Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein. J Virol 82 (8), 4082 (2008).

Verma, S. C. et al., An autonomous replicating element within the KSHV genome. Cell Host Microbe 2 (2), 106 (2007).

Verma, S. C., Choudhuri, T., and Robertson, E. S., The minimal replicator element of the Kaposi's sarcoma-associated herpesvirus terminal repeat supports replication in a semiconservative and cell-cycle-dependent manner. J Virol 81 (7), 3402 (2007).

Lan, K. et al., Isolation of human peripheral blood mononuclear cells (PBMCs). Curr Protoc Microbiol Appendix 4, Appendix 4C (2007).

Lan, K. et al., Epstein-Barr Virus (EBV): infection, propagation, quantitation, and storage. Curr Protoc Microbiol Chapter 14, Unit 14E 2 (2007).

Lan, K. et al., Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein. Proc Natl Acad Sci U S A 104 (41), 16287 (2007).

Kaul, R., Verma, S. C., and Robertson, E. S., Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA. Virology 364 (2), 317 (2007).

Kaul, R., Murakami, M., Choudhuri, T., and Robertson, E. S., Epstein-Barr virus latent nuclear antigens can induce metastasis in a nude mouse model. J Virol 81 (19), 10352 (2007).

Choudhuri, T. et al., The ATM/ATR signaling effector Chk2 is targeted by Epstein-Barr virus nuclear antigen 3C to release the G2/M cell cycle block. J Virol 81 (12), 6718 (2007).

Cai, Q., Murakami, M., Si, H., and Robertson, E. S., A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia. J Virol 81 (19), 10413 (2007).

Bajaj, B. G., Murakami, M., and Robertson, E. S., Molecular biology of EBV in relationship to AIDS-associated oncogenesis. Cancer Treat Res 133, 141 (2007).

Verma, S. C., Lan, K., Choudhuri, T., and Robertson, E. S., Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen modulates K1 expression through its cis-acting elements within the terminal repeats. J Virol 80 (7), 3445 (2006).

Verma, S. C., Choudhuri, T., Kaul, R., and Robertson, E. S., Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats. J Virol 80 (5), 2243 (2006).

Verma, S. C. et al., Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus. J Virol 80 (22), 11178 (2006).

Si, H., Verma, S. C., and Robertson, E. S., Proteomic analysis of the Kaposi's sarcoma-associated herpesvirus terminal repeat element binding proteins. J Virol 80 (18), 9017 (2006).

Si, H. and Robertson, E. S., Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function. J Virol 80 (2), 697 (2006).

Sharma, N., Knight, J. S., and Robertson, E. S., Conserved cell cycle regulatory properties within the amino terminal domain of the Epstein-Barr virus nuclear antigen 3C. Virology 346 (2), 379 (2006).

Lan, K. et al., Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latency. Virology 351 (2), 393 (2006).

Lan, K. et al., Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro. J Virol 80 (13), 6411 (2006).

Knight, J. S. et al., A peptide-based inhibitor for prevention of B cell hyperproliferation induced by Epstein-Barr virus. Virology 354 (1), 207 (2006).

Kaul R, Verma SC, Murakami M, Lan K, Choudhuri T, Robertson ES. Epstein-Barr virus protein can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1. J Virol. 2006 Feb;80(3):1321-31.

Si H, Robertson ES. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function. J Virol. 2006 Jan;80(2):697-709.

Sharma N, Knight JS, Robertson ES.Conserved cell cycle regulatory properties within the amino terminal domain of the Epstein-Barr virus nuclear antigen 3C. Virology. 2005 Dec 15

Knight JS, Sharma N, Robertson ES. Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18562-6.

Kuppers DA, Lan K, Knight JS, Robertson ES. Regulation of matrix metalloproteinase 9 expression by Epstein-Barr virus nuclear antigen 3C and the suppressor of metastasis Nm23-H1.J Virol. 2005 Aug;79(15):9714-24.

Lan K, Kuppers DA, Verma SC, Sharma N, Murakami M, Robertson ES. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency.J Virol. 2005Jun;79(12):7453-65.

Lan K, Kuppers DA, Robertson ES. Kaposi's Sarcoma-Associated Herpesvirus Reactivation Is Regulated by Interaction of Latency-Associated Nuclear Antigen with Recombination Signal Sequence-Binding Protein J{kappa}, the Major Downstream Effector of the Notch Signaling Pathway. J Virol. 2005 Mar;79(6):3468-78.

Knight JS, Sharma N, Robertson ES. SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen. Mol Cell Biol. 2005 Mar;25(5):1749-63.

Murakami M, Lan K, Subramanian C, Robertson ES. Epstein-Barr virus nuclear antigen 1 interacts with Nm23-H1 in lymphoblastoid cell lines and inhibits its ability to suppress cell migration. J Virol. 2005Feb;79(3):1559-68.

Knight, J.S., Sharma, N., Kalman, D.E. and E.S. Robertson, A Cyclin-Binding Motif within the Amino-Terminal Homology Domain of EBNA3C Binds Cyclin A and Modulates Cyclin A-Dependent Kinase Activity in EBV-Infected Cells. J Virol. 2004 Dec;78(23):12857-67.

Verma, S.C., Borah, S., and E.S. Robertson, The Latency Associated Nuclear Antigen of Kaposi's Sarcoma Associated Herpesvirus up-regulates Transcription of Human Telomerase Reverse Transcriptase (hTERT) Promoter through Interaction with the Sp1 Transcription Factor. J Virol. 2004 Oct;78(19):10348-59.

Borah, S., Verma, S.C., and E.S. Robertson, The orf73 of Herpesvirus saimiri, a viral homolog of Kaposi's Sarcoma Associated Herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb. J Virol. 2004 Oct;78(19):10336-47.

Lan, K., Kuppers, D.A., Verma, S.C. and Robertson, E.S., Kaposi's sarcoma Associated Herpesvirus Encoded Latency Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: A Potential Mechanism for Viral Mediated Control of Letency. J Virol. 2004 Jun;78(12):p. 6585-94.

Knight, J.S. and Robertson, E.S., Epstein-Barr Virus Nuclear Antigen 3C regulates Cyclin A/p27 Complexes and Enhances Cyclin A-Dependent Kinase Activity. J. Virol, 2004. 78(4):p. 1981-91.

Sisk, E.A., et al., Epstein-Barr virus detected in a head and neck squamous cell carcinoma cell line derived from an immunocompromised patient. Arch Otolaryngol Head Neck Surg, 2003. 129(10): p. 1115-24.

Verma, S.C. and E.S. Robertson, ORF73 of herpesvirus Saimiri strain C488 tethers the viral genome to metaphase chromosomes and binds to cis-acting DNA sequences in the terminal repeats. J Virol, 2003. 77(23): p. 12494-506.

Knight, J.S., et al., Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines. J Virol, 2003. 77(7): p. 4261-72.

Verma, S.C. and E.S. Robertson, Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol Lett, 2003. 222(2): p. 155-63.

Lin, J., et al., Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2. J Virol, 2002. 76(1): p. 232-42.

Subramanian, C., J.S. Knight, and E.S. Robertson, The Epstein Barr nuclear antigen EBNA3C regulates transcription, cell transformation and cell migration. Front Biosci,2002. 7: p. d704-16.

Subramanian, C., et al., Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation. J Virol, 2002. 76(10): p. 4699-708.

Subramanian, C. and E.S. Robertson, The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcription. J Virol, 2002. 76(17): p. 8702-9.

Orre, R.S., et al., Prothymosin alpha functions as a cellular oncoprotein by inducing transformation of rodent fibroblasts in vitro. J Biol Chem, 2001. 276(3): p. 1794-9.

Subramanian, C., M.A. Cotter, 2nd, and E.S. Robertson, Epstein-Barr virus nuclear protein EBNA-3C interacts with the human metastatic suppressor Nm23-H1: a molecular link to cancer metastasis. Nat Med, 2001. 7(3): p. 350-5.

Knight, J.S., M.A. Cotter, 2nd, and E.S. Robertson, The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter. J Biol Chem, 2001. 276(25): p. 22971-8.

Cotter, M.A., 2nd, C. Subramanian, and E.S. Robertson, The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminus. Virology, 2001. 291(2): p. 241-59.

Book Chapters

1. Knight, J.S., Verma, S.C., Lan, K., and Robertson, E.S., Molecular genetics of Herpesvirus recombinant technology. In “Methods in Molecular Biology” (2003).

2. Verma, S.C. Lan, K. Woodman, Z.L., and Robertson, E.S., Developments in understanding the mechanism of tumorigenesis mediated by Kaposi’s sarcoma associated herpesvirus. In Progress in Virus Research” Nova Science Publishers, France (2003)

3. Knight JS, Verma SC, Lan K, Robertson ES. Related Articles, Links
Abstract Molecular genetics of herpesviruses: a recombinant technology approach.
Methods Mol Biol. 2005;292:333-52.

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