Ke Lan, MD, PhD
Research Associate

202B Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104-6076
(215) 746-0116

lanke@mail.med.upenn.edu

Curriculum Vitae

Mechanism of Inhibition of Viral Lytic Replication by Kaposi’s Sarcoma Associated Herpesvirus Encoded Latency Associated Nuclear Antigen

Construction of a KSHV-GFP Recombinant Virus and the Development of a System to Assess Gene functions of KSHV

M.D. (1994) Chongging Medical University, China
M.Sc. (1998) Chongging Medical University, China
Ph.D. (2001) Cancer Research Institute, Xiang Ya Medical School, Central South University, China

Atlantic City
Camping
Straw Berry
Department of Microbiology
In the Lab
With Jason & Subhash
Mi Lan & Me
New York
Poster
Waterfall

1. Knight JS, Lan K, Subramanian C, and Robertson ES. Epstein Barr Virus Nuclear Antigen 3C Recruits Histone Deacetylase Activity and Associates with the Corepressors mSin3A and NCoR in Human B-Cell Lines. Journal of Virology. 77: 4261-4272, 2003 April.

2. Knight JS, Verma CS, Lan K, and Robertson ES. Molecular Genetics of Herpesviruses: A Recombinant Technology Approach. Methods in Molecular Biology: DNA Viruses. The Humana Press Inc. Methods Mol Biol. 2005;292:333-52.

3. Ke Lan, Daniel A. Kuppers, Subhash C. Verma, and Erle S. Robertson. Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency. Journal of Virology. 78: 6585-6594, 2004 June

4. Murakami M, Lan K, Subramanian C and Robertson ES. Inhibition of cell migration by Nm23-H1 is suppressed by Epstein-Barr virus Nuclear Antigen 1 and forms a complex in immortalized B-lymphoblastoid cell lines. Journal of Virology 2005 Feb;79(3):1559-68.

5. Lan K, Kuppers D, and Robertson ES. KSHV Reactivation is Regulated by Interaction of LANA with RBP-J , the Major Downstream Effector of the Notch Signaling Pathway. Journal of Virology 2005 Mar;79(6):3468-78

6. Lan K, Kuppers D, and Robertson ES. Induction of KSHV Latency Associated Nuclear Antigen by the Lytic Transactivator RTA: A Novel Mechanism for Establishment of Latency. Journal of Virology 2005 Jun;79(12):7453-65.

7. Lan K, Kupper D, and Robertson ES. Intracellular Notch1 Determines the Oncogenic Phenotype of KSHV Related B Cell Lymphoma. Submitted.

8. Kuppers D, Lan K, and Robertson ES. Regulation of MMP-9 Expression by Epstein-Barr Virus Nuclear Antigen 3C and the Suppressor of Metastasis Nm23-H1. Journal of Virology, 2005 Aug;79(15):9714-24.

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